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Upfront Ventures

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About Upfront Ventures

Investor type

VC firm

First check

$1M to $8M

Lead

Always

Themes

mRNA
life sciences
IVD
CBD
in vitro diagnostics
life-science
machine learning
life science
diversity
therapeutics
longevity
CGT
underestimated founders
SaaS
molecules
ML
healthcare
health
digital-health
healthtech
female founded
agents
medical device
immigrant
genAI
people of color
immigrants
mental health
drugs
artificial intelligence
med device
under-represented
inclusion
latina
diagnostics
Immigrant (1st or 2nd generation)
cannabis biotech
first generation
psychedelic
medtech
diverse
machine vision
age tech
biopharma
wellbeing
subscription
lifescience
health-tech
immigrant founders
silvertech
biomarkers
bio
female led
underrepresented founders
D&I
inclusive
transcriptomics
silver economy
US Military Veteran
drug
protein
woman-led
recurring
woman led
tech-enabled health
historically ignored founder
female-founded
LGBT
metabolomics
well-being
telehealth
disabled
ehealth
overlooked teams
lifesciences
connected health
computer vision
female
femtech
gay
woman
biomarker
big data
woman-lead
second generation
therapy
African American
female-led
agetech
bioimaging
last mile
latinx
medical devices
celle therapy
healthier living
data science
women
female founder
female entrepreneur
eldertech
connected-health
psychedelics
e-health
life sciences tools
delivery
neural network
wellness
women-led
lesbian
latino
medicine
LLM
pharma
cell therapy
aging
medicines
therapeutic
proteomics
African-American
black
deep learning
woman lead
BIPOC
generative AI
women's
second-generation
pharmaceuticals
first-generation
female founders
metabolites
genomics AI
gene therapy
+127
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Funding Stages

1. Idea or Patent2. Prototype3. Early Revenue4. Scaling

Countries of investment

Flag of UK UKFlag of USA USAFlag of Canada Canada

Who we are

Upfront Ventures is LA’s original venture firm, backing breakout companies at the earliest stages. With $2B+ AUM and over 25 years of investing, we lead early rounds in healthtech, biotech, and beyond—supporting founders from first check through scale.

Funding Requirements

We invest in healthtech, biotech, life sciences, digital health, diagnostics, therapeutics, care delivery, value-based care, healthcare SaaS, mental health, women’s health, aging, AI/ML in healthcare, and regulated healthcare services.

Value add

I started my career as a clinician because I wanted to help people heal — and I bring that same lens to investing. I’ve led clinical strategy at scaling startups, built partnerships across payers and providers, and lived the complexity of care delivery from the inside. I back founders building what should already exist — and roll up my sleeves to help them do it.

Locations

1314 7th St, Santa Monica, CA 90401 HQ

Upfront Ventures Team

Christina Fattore

Christina Fattore

Associate

"Clinician turned operator turned investor - backing HC companies solving real problems by people who actually care."

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