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Upfront Ventures

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About Upfront Ventures

Investor type

VC firm

First check

$1M to $8M

Lead

Always

Themes

latinx
female founder
disabled
mRNA
connected-health
healthcare
therapeutic
femtech
recurring
cell therapy
historically ignored founder
therapy
silver economy
inclusion
wellness delivery
molecules
woman lead
black
cannabis
agetech
drug
woman-lead
celle therapy
pharma
female-founded
pharmaceuticals
woman
female-led
health
first generation
AI
generative AI
biotech
biopharma
female founded
people of color
African American
life sciences
metabolites
transcriptomics
well-being
drugs
first-generation
woman-led
latino
lifescience
latina
psychedelics
overlooked teams
Immigrant (1st or 2nd generation)
CBD
telehealth
women-led
immigrant founders
diagnostics
digital-health
underestimated founders
machine vision
protein
lesbian
D&I
computer vision
psychedelic
biomarker
female entrepreneur
LLM
biomarkers
med device
subscription
underrepresented founders
health-tech
diverse
immigrants
healthier living
life sciences tools
mental health
metabolomics
artificial intelligence
data science
LGBT
aging
in vitro diagnostics
diversity
second generation
life-science
agents
CGT
deep learning
genomics
female led
medtech
life science
under-represented
SaaS
women's
immigrant
therapeutics
ehealth
silvertech
female
longevity
female founders
lifesciences
age tech
US Military Veteran
machine learning
tech-enabled health
eldertech
bio
African-American
bioimaging
last mile
gay
wellbeing
inclusive
second-generation
neural network
big data medical device
e-health
BIPOC
medical devices
gene therapy
medicine
healthtech
proteomics
genAI
ML
woman led
medicines
IVD
connected health
women
+127
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Funding Stages

1. Idea or Patent2. Prototype3. Early Revenue4. Scaling

Countries of investment

Flag of UK UKFlag of USA USAFlag of Canada Canada

Who we are

Upfront Ventures is LA’s original venture firm, backing breakout companies at the earliest stages. With $2B+ AUM and over 25 years of investing, we lead early rounds in healthtech, biotech, and beyond—supporting founders from first check through scale.

Funding Requirements

We invest in healthtech, biotech, life sciences, digital health, diagnostics, therapeutics, care delivery, value-based care, healthcare SaaS, mental health, women’s health, aging, AI/ML in healthcare, and regulated healthcare services.

Value add

I started my career as a clinician because I wanted to help people heal — and I bring that same lens to investing. I’ve led clinical strategy at scaling startups, built partnerships across payers and providers, and lived the complexity of care delivery from the inside. I back founders building what should already exist — and roll up my sleeves to help them do it.

Locations

1314 7th St, Santa Monica, CA 90401 HQ

Upfront Ventures Team

Christina Fattore

Christina Fattore

Associate

"Clinician turned operator turned investor - backing HC companies solving real problems by people who actually care."

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