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Upfront Ventures

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About Upfront Ventures

Investor type

VC firm

First check

$1M to $8M

Lead

Always

Themes

disabled
pharma
femtech
latina
woman
women's
D&I
celle therapy
woman led
metabolites
age tech
female entrepreneur
bioimaging
biopharma
inclusion
gene therapy
connected-health
women-led
underestimated founders
female founder
woman lead
cell therapy
healthier living
immigrant founders
medicines
medtech
first-generation
biomarker
delivery
recurring
eldertech
LLM
health
LGBT
female founded
artificial intelligence
latinx
neural network
medical device
historically ignored founder
life sciences
agents
IVD
female-led
pharmaceuticals
healthtech
proteomics
life science
lesbian
computer vision
lifesciences
connected health
therapeutics
mental health AI big data
e-health
immigrant
SaaS
silver economy
female founders
medicine
deep learning
in vitro diagnostics
life-science
black
African-American
subscription
silvertech
woman-led
genomics
diverse
bio
life sciences tools
telehealth
ML
diagnostics
immigrants
woman-lead
mRNA
protein
BIPOC
CGT
under-represented
second-generation
therapeutic
first generation
ehealth
women
cannabis
transcriptomics
female-founded
people of color
wellbeing
aging
drugs
healthcare
CBD
psychedelics
female led
underrepresented founders
therapy
female
data science
health-tech
psychedelic
digital-health
biotech
machine learning
metabolomics
wellness
last mile
inclusive
overlooked teams
US Military Veteran
medical devices
gay
longevity
molecules
African American
med device
tech-enabled health
second generation
diversity
well-being
drug
biomarkers
latino
machine vision
genAI
Immigrant (1st or 2nd generation)
lifescience
generative AI
agetech
+127
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Funding Stages

1. Idea or Patent2. Prototype3. Early Revenue4. Scaling

Countries of investment

Flag of UK UKFlag of USA USAFlag of Canada Canada

Who we are

Upfront Ventures is LA’s original venture firm, backing breakout companies at the earliest stages. With $2B+ AUM and over 25 years of investing, we lead early rounds in healthtech, biotech, and beyond—supporting founders from first check through scale.

Funding Requirements

We invest in healthtech, biotech, life sciences, digital health, diagnostics, therapeutics, care delivery, value-based care, healthcare SaaS, mental health, women’s health, aging, AI/ML in healthcare, and regulated healthcare services.

Value add

I started my career as a clinician because I wanted to help people heal — and I bring that same lens to investing. I’ve led clinical strategy at scaling startups, built partnerships across payers and providers, and lived the complexity of care delivery from the inside. I back founders building what should already exist — and roll up my sleeves to help them do it.

Locations

1314 7th St, Santa Monica, CA 90401 HQ

Upfront Ventures Team

Christina Fattore

Christina Fattore

Associate

“Clinician turned operator turned investor - backing HC companies solving real problems by people who actually care.”

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