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Upfront Ventures

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About Upfront Ventures

Investor type

VC firm

First check

$1M to $8M

Lead

Always

Themes

tech-enabled health
big data
metabolites
historically ignored founder
silvertech
connected-health
immigrant
CGT
AI
data science
celle therapy
underrepresented founders
medical device
life sciences tools
pharma
agetech
ehealth
protein
silver economy
lesbian
first generation
therapeutic
medical devices
digital-health
latino
CBD
mental health
in vitro diagnostics
overlooked teams
US Military Veteran
women's
female-founded
medtech
black
wellbeing
female-led
diagnostics
disabled
lifesciences
immigrant founders
bio
latina
LGBT
LLM
healthcare
wellness
eldertech
second generation
first-generation
immigrants
drugs
inclusive
therapeutics
life science
computer vision
medicine
ML
med device
drug
cannabis delivery genomics
health-tech
gay
diversity
subscription
telehealth
diverse
D&I
biomarkers
lifescience
last mile
genAI
bioimaging
metabolomics
biomarker
female entrepreneur
recurring
neural network
deep learning
biotech
medicines
woman lead
e-health
African American
women-led
African-American
connected health
health
biopharma
Immigrant (1st or 2nd generation)
mRNA
woman
gene therapy
well-being
healthier living
artificial intelligence
pharmaceuticals
woman led
underestimated founders
femtech
female founder
longevity
inclusion
second-generation
female founded
proteomics
woman-led
cell therapy
IVD
therapy
age tech
machine learning
aging
life sciences
female led
people of color
psychedelicshealthtech
transcriptomics
female
life-science
psychedelic
female founders
latinx
women
SaaS
woman-lead
agents
generative AI
under-represented
BIPOC
molecules
machine vision
+127
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Funding Stages

1. Idea or Patent2. Prototype3. Early Revenue4. Scaling

Countries of investment

Flag of UK UKFlag of USA USAFlag of Canada Canada

Who we are

Upfront Ventures is LA’s original venture firm, backing breakout companies at the earliest stages. With $2B+ AUM and over 25 years of investing, we lead early rounds in healthtech, biotech, and beyond—supporting founders from first check through scale.

Funding Requirements

We invest in healthtech, biotech, life sciences, digital health, diagnostics, therapeutics, care delivery, value-based care, healthcare SaaS, mental health, women’s health, aging, AI/ML in healthcare, and regulated healthcare services.

Value add

I started my career as a clinician because I wanted to help people heal — and I bring that same lens to investing. I’ve led clinical strategy at scaling startups, built partnerships across payers and providers, and lived the complexity of care delivery from the inside. I back founders building what should already exist — and roll up my sleeves to help them do it.

Locations

1314 7th St, Santa Monica, CA 90401 HQ

Upfront Ventures Team

Christina Fattore

Christina Fattore

Associate

"Clinician turned operator turned investor - backing HC companies solving real problems by people who actually care."

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