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Top Venture Capital Firms and Investors in San Diego

Explore OpenVC’s list of San Diego venture capital firms, angel investors, and startup accelerators. Find investors who share your vision and scale your business with confidence.

Last update: July 8, 2026

List author: Devon Wood

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What Are the Top Investors in San Diego?

1. Section 32

A healthcare and enterprise-focused venture firm spun out of Google Ventures. Section 32 is one of the most influential investors in San Diego’s biotech and life sciences ecosystem.

2. Qualcomm Ventures

The corporate venture arm of Qualcomm. Deeply embedded in San Diego’s tech scene, with strong activity in wireless, semiconductors, AI, and deep tech.

3. Avalon Ventures

A long-standing San Diego venture firm best known for early-stage biotech and life sciences company creation. Avalon has launched and backed dozens of local startups.

4. Domain Associates

One of the most established biotech-focused venture capital firms in San Diego. Domain has played a major role in building the region’s life sciences reputation.

5. Scripps Ventures

The venture arm connected to Scripps Research. Highly respected in biotech, therapeutics, and translational science coming out of San Diego research institutions.

6. Tech Coast Angels (San Diego chapter)

One of the largest and most active angel networks in Southern California. Tech Coast Angels is often the first institutional capital for San Diego startups.

7. San Diego Angel Conference

A unique angel-led investment vehicle that pools capital from local angels and invests annually in a small number of early-stage startups.

8. Fifty Years

An impact-focused venture fund with strong ties to San Diego’s startup and university ecosystems. Known for backing science-driven companies with long-term missions.

9. TCA Venture Group

A regional angel investment group active across Southern California, including San Diego. Known for syndicating early-stage deals alongside founders and VCs.

10. March Capital

While now multi-city, March Capital has deep San Diego roots and remains one of the most recognized venture firms associated with the region’s tech growth.

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